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- Title
Production of functional glucagon-secreting α-cells from human embryonic stem cells.
- Authors
Rezania, Alireza; Riedel, Michael J; Wideman, Rhonda D; Karanu, Francis; Ao, Ziliang; Warnock, Garth L; Kieffer, Timothy J
- Abstract
Differentiation of human embryonic stem (hES) cells to fully developed cell types holds great therapeutic promise. Despite significant progress, the conversion of hES cells to stable, fully differentiated endocrine cells that exhibit physiologically regulated hormone secretion has not yet been achieved. Here we describe an efficient differentiation protocol for the in vitro conversion of hES cells to functional glucagon-producing α- cells.
- Publication
Diabetes, 2011, Vol 60, Issue 1, p239
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-0573