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- Title
Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes.
- Authors
Jurewicz, Mollie; Yang, Sunmi; Augello, Andrea; Godwin, Jonathan G; Moore, Robert F; Azzi, Jamil; Fiorina, Paolo; Atkinson, Mark; Sayegh, Mohamed H; Abdi, Reza
- Abstract
A number of clinical trials are underway to test whether mesenchymal stem cells (MSCs) are effective in treating various diseases, including type 1 diabetes. Although this cell therapy holds great promise, the optimal source of MSCs has yet to be determined with respect to major histocompatibility complex matching. Here, we examine this question by testing the ability of congenic MSCs, obtained from the NOR mouse strain, to reverse recent-onset type 1 diabetes in NOD mice, as well as determine the immunomodulatory effects of NOR MSCs in vivo.
- Publication
Diabetes, 2010, Vol 59, Issue 12, p3139
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-0542