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- Title
Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.
- Authors
Noso, Shinsuke; Kataoka, Kohsuke; Kawabata, Yumiko; Babaya, Naru; Hiromine, Yoshihisa; Yamaji, Kaori; Fujisawa, Tomomi; Aramata, Shinsaku; Kudo, Takashi; Takahashi, Satoru; Ikegami, Hiroshi
- Abstract
Tissue-specific self-antigens are ectopically expressed within the thymus and play an important role in the induction of central tolerance. Insulin is expressed in both pancreatic islets and the thymus and is considered to be the primary antigen for type 1 diabetes. Here, we report the role of the insulin transactivator MafA in the expression of insulin in the thymus and susceptibility to type 1 diabetes.
- Publication
Diabetes, 2010, Vol 59, Issue 10, p2579
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db10-0476