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Title
A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease.
Authors
Mori, Marcelo A; Liu, Manway; Bezy, Olivier; Almind, Katrine; Shapiro, Hagit; Kasif, Simon; Kahn, C Ronald
Abstract
Type 2 diabetes and obesity are increasingly affecting human populations around the world. Our goal was to identify early molecular signatures predicting genetic risk to these metabolic diseases using two strains of mice that differ greatly in disease susceptibility.