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- Title
P-selectin glycoprotein ligand-1 deficiency is protective against obesity-related insulin resistance.
- Authors
Sato, Chikage; Shikata, Kenichi; Hirota, Daisho; Sasaki, Motofumi; Nishishita, Shingo; Miyamoto, Satoshi; Kodera, Ryo; Ogawa, Daisuke; Tone, Atsuhito; Kataoka, Hitomi Usui; Wada, Jun; Kajitani, Nobuo; Makino, Hirofumi
- Abstract
An inflammatory process is involved in the mechanism of obesity-related insulin resistance. Recent studies indicate that monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that promotes monocyte infiltration into adipose tissues; however, the adhesion pathway in adipose tissues remains unclear. We aimed to clarify the adhesion molecules that mediate monocyte infiltration into adipose tissue.
- Publication
Diabetes, 2011, Vol 60, Issue 1, p189
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-1894