We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes.
- Authors
Gupta, Dhananjay; Peshavaria, Mina; Monga, Navjot; Jetton, Thomas L; Leahy, Jack L
- Abstract
We previously showed that peroxisome proliferator-activated receptor (PPAR)-gamma in beta-cells regulates pdx-1 transcription through a functional PPAR response element (PPRE). Gene Bank blast for a homologous nucleotide sequence revealed the same PPRE within the rat glucose-dependent insulinotropic polypeptide receptor (GIP-R) promoter sequence. We investigated the role of PPARgamma in GIP-R transcription.
- Publication
Diabetes, 2010, Vol 59, Issue 6, p1445
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-1655