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- Title
Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.
- Authors
Muller, Yunhua L; Hanson, Robert L; Bian, Li; Mack, Janel; Shi, Xiaolian; Pakyz, Ruth; Shuldiner, Alan R; Knowler, William C; Bogardus, Clifton; Baier, Leslie J
- Abstract
MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes.
- Publication
Diabetes, 2010, Vol 59, Issue 8, p2080
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-1593