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- Title
Δ40 Isoform of p53 controls β-cell proliferation and glucose homeostasis in mice.
- Authors
Hinault, Charlotte; Kawamori, Dan; Liew, Chong Wee; Maier, Bernhard; Hu, Jiang; Keller, Susanna R; Mirmira, Raghavendra G; Scrable, Heidi; Kulkarni, Rohit N
- Abstract
Investigating the dynamics of pancreatic β-cell mass is critical for developing strategies to treat both type 1 and type 2 diabetes. p53, a key regulator of the cell cycle and apoptosis, has mostly been a focus of investigation as a tumor suppressor. Although p53 alternative transcripts can modulate p53 activity, their functions are not fully understood. We hypothesized that β-cell proliferation and glucose homeostasis were controlled by Δ40p53, a p53 isoform lacking the transactivation domain of the full-length protein that modulates total p53 activity and regulates organ size and life span in mice.
- Publication
Diabetes, 2011, Vol 60, Issue 4, p1210
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-1379