We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes.
- Authors
Saisho, Yoshifumi; Manesso, Erica; Butler, Alexandra E; Galasso, Ryan; Kavanagh, Kylie; Flynn, Mickey; Zhang, Li; Clark, Paige; Gurlo, Tatyana; Toffolo, Gianna M; Cobelli, Claudio; Wagner, Janice D; Butler, Peter C
- Abstract
β-Cell turnover and its potential to permit β-cell regeneration in adult primates are unknown. Our aims were 1) to measure β-cell turnover in adult nonhuman primates; 2) to establish the relative contribution of β-cell replication and formation of new β-cells from other precursors (defined thus as β-cell neogenesis); and 3) to establish whether there is an adaptive increase in β-cell formation (attempted regeneration) in streptozotocin (STZ)-induced diabetes in adult nonhuman primates.
- Publication
Diabetes, 2011, Vol 60, Issue 3, p848
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-1368