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- Title
Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.
- Authors
Ussher, John R; Koves, Timothy R; Cadete, Virgilio J J; Zhang, Liyan; Jaswal, Jagdip S; Swyrd, Suzanne J; Lopaschuk, David G; Proctor, Spencer D; Keung, Wendy; Muoio, Deborah M; Lopaschuk, Gary D
- Abstract
It has been proposed that skeletal muscle insulin resistance arises from the accumulation of intramyocellular lipid metabolites that impede insulin signaling, including diacylglycerol and ceramide. We determined the role of de novo ceramide synthesis in mediating muscle insulin resistance.
- Publication
Diabetes, 2010, Vol 59, Issue 10, p2453
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-1293