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- Title
TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.
- Authors
An, Ding; Toyoda, Taro; Taylor, Eric B; Yu, Haiyan; Fujii, Nobuharu; Hirshman, Michael F; Goodyear, Laurie J
- Abstract
TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the function of TBC1D1 in muscle is not known. Genetic linkage analyses show a TBC1D1 R125W missense variant confers risk for severe obesity in humans. The objective of this study was to determine whether TBC1D1 regulates glucose transport in skeletal muscle.
- Publication
Diabetes, 2010, Vol 59, Issue 6, p1358
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-1266