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- Title
Prevalence of loss-of-function FTO mutations in lean and obese individuals.
- Authors
Meyre, David; Proulx, Karine; Kawagoe-Takaki, Hiroko; Vatin, Vincent; Gutiérrez-Aguilar, Ruth; Lyon, Debbie; Ma, Marcella; Choquet, Helene; Horber, Fritz; Van Hul, Wim; Van Gaal, Luc; Balkau, Beverley; Visvikis-Siest, Sophie; Pattou, François; Farooqi, I Sadaf; Saudek, Vladimir; O'Rahilly, Stephen; Froguel, Philippe; Sedgwick, Barbara; Yeo, Giles S H
- Abstract
Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass- and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(-/-) mice are lean and Fto(+/-) mice are resistant to diet-induced obesity. We aimed to determine whether FTO mutations are disproportionately represented in lean or obese humans and to use these mutations to understand structure-function relationships within FTO.
- Publication
Diabetes, 2010, Vol 59, Issue 1, p311
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-0703