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- Title
Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity.
- Authors
Miyashita, Kazutoshi; Itoh, Hiroshi; Tsujimoto, Hirokazu; Tamura, Naohisa; Fukunaga, Yasutomo; Sone, Masakatsu; Yamahara, Kenichi; Taura, Daisuke; Inuzuka, Megumi; Sonoyama, Takuhiro; Nakao, Kazuwa
- Abstract
Natriuretic peptides (NPs) have been characterized as vascular hormones that regulate vascular tone via guanylyl cyclase (GC), cyclic GMP (cGMP), and cGMP-dependent protein kinase (cGK). Recent clinical studies have shown that plasma NP levels were lower in subjects with the metabolic syndrome. The present study was conducted to elucidate the roles for NP/cGK cascades in energy metabolism.
- Publication
Diabetes, 2009, Vol 58, Issue 12, p2880
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-0393