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- Title
Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.
- Authors
Herold, Kevan C; Brooks-Worrell, Barbara; Palmer, Jerry; Dosch, H Michael; Peakman, Mark; Gottlieb, Peter; Reijonen, Helena; Arif, Sefina; Spain, Lisa M; Thompson, Clinton; Lachin, John M; Type 1 Diabetes TrialNet Research Group
- Abstract
Type 1 diabetes results from an immunemediated destruction of beta-cells, likely to be mediated by T lymphocytes, but the sensitivity, specificity, and other measures of validity of existing assays for islet autoreactive T-cells are not well established. Such assays are vital for monitoring responses to interventions that may modulate disease progression.
- Publication
Diabetes, 2009, Vol 58, Issue 11, p2588
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-0249