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- Title
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop.
- Authors
Cornu, Marion; Yang, Jiang-Yan; Jaccard, Evrim; Poussin, Carine; Widmann, Christian; Thorens, Bernard
- Abstract
The gluco-incretin hormones glucagon-like peptide (GLP)-1 and gastric inhibitory peptide (GIP) protect beta-cells against cytokine-induced apoptosis. Their action is initiated by binding to specific receptors that activate the cAMP signaling pathway, but the downstream events are not fully elucidated. Here we searched for mechanisms that may underlie this protective effect.
- Publication
Diabetes, 2009, Vol 58, Issue 8, p1816
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-0063