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- Title
Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1.
- Authors
Vincent, Andrea M; Hayes, John M; McLean, Lisa L; Vivekanandan-Giri, Anuradha; Pennathur, Subramaniam; Feldman, Eva L
- Abstract
Neuropathy is a frequent and severe complication of diabetes. Multiple metabolic defects in type 2 diabetic patients result in oxidative injury of dorsal root ganglia (DRG) neurons. Our previous work focused on hyperglycemia clearly demonstrates induction of mitochondrial oxidative stress and acute injury in DRG neurons; however, this mechanism is not the only factor that produces neuropathy in vivo. Dyslipidemia also correlates with the development of neuropathy, even in pre-diabetic patients. This study was designed to explore the contribution of dyslipidemia in neuropathy.
- Publication
Diabetes, 2009, Vol 58, Issue 10, p2376
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db09-0047