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- Title
Endoplasmic reticulum stress regulates adipocyte resistin expression.
- Authors
Lefterova, Martina I; Mullican, Shannon E; Tomaru, Takuya; Qatanani, Mohammed; Schupp, Michael; Lazar, Mitchell A
- Abstract
Resistin is a secreted polypeptide that impairs glucose metabolism and, in rodents, is derived exclusively from adipocytes. In murine obesity, resistin circulates at elevated levels but its gene expression in adipose tissue is paradoxically reduced. The mechanism behind the downregulation of resistin mRNA is poorly understood. We investigated whether endoplasmic reticulum (ER) stress, which is characteristic of obese adipose tissue, regulates resistin expression in cultured mouse adipocytes.
- Publication
Diabetes, 2009, Vol 58, Issue 8, p1879
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-1706