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- Title
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
- Authors
Estall, Jennifer L; Kahn, Mario; Cooper, Marcus P; Fisher, Ffolliott Martin; Wu, Michele K; Laznik, Dina; Qu, Lishu; Cohen, David E; Shulman, Gerald I; Spiegelman, Bruce M
- Abstract
The peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1 family of transcriptional coactivators controls hepatic function by modulating the expression of key metabolic enzymes. Hepatic gain of function and complete genetic ablation of PGC-1alpha show that this coactivator is important for activating the programs of gluconeogenesis, fatty acid oxidation, oxidative phosphorylation, and lipid secretion during times of nutrient deprivation. However, how moderate changes in PGC-1alpha activity affect metabolism and energy homeostasis has yet to be determined.
- Publication
Diabetes, 2009, Vol 58, Issue 7, p1499
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-1571