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- Title
Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.
- Authors
Du, Aiping; Hunter, Chad S; Murray, Johanna; Noble, Daniel; Cai, Chen-Leng; Evans, Sylvia M; Stein, Roland; May, Catherine Lee
- Abstract
The generation of mature cell types during pancreatic development depends on the expression of many regulatory and signaling proteins. In this study, we tested the hypothesis that the transcriptional regulator Islet-1 (Isl-1), whose expression is first detected in the mesenchyme and epithelium of the developing pancreas and is later restricted to mature islet cells, is involved in the terminal differentiation of islet cells and maintenance of islet mass.
- Publication
Diabetes, 2009, Vol 58, Issue 9, p2059
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-0987