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- Title
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin.
- Authors
Rahmouni, Kamal; Sigmund, Curt D; Haynes, William G; Mark, Allyn L
- Abstract
Leptin is an adipocyte hormone that plays a major role in energy balance. Leptin receptors in the hypothalamus are known to signal via distinct mechanisms, including signal transducer and activator of transcription-3 (STAT3) and phosphoinositol-3 kinase (PI 3-kinase). Here, we tested the hypothesis that extracellular signal-regulated kinase (ERK) is mediating leptin action in the hypothalamus.
- Publication
Diabetes, 2009, Vol 58, Issue 3, p536
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-0822