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Title
Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice.
Authors
Suarez-Pinzon, Wilma L; Power, Robert F; Yan, Yanhua; Wasserfall, Clive; Atkinson, Mark; Rabinovitch, Alex
Abstract
Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic beta-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the beta-cell mass and reverse hyperglycemia in NOD mice with autoimmune diabetes.