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- Title
High glucose induces toll-like receptor expression in human monocytes: mechanism of activation.
- Authors
Dasu, Mohan R; Devaraj, Sridevi; Zhao, Ling; Hwang, Daniel H; Jialal, Ishwarlal
- Abstract
Hyperglycemia-induced inflammation is central in diabetes complications, and monocytes are important in orchestrating these effects. Toll-like receptors (TLRs) play a key role in innate immune responses and inflammation. However, there is a paucity of data examining the expression and activity of TLRs in hyperglycemic conditions. Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions.
- Publication
Diabetes, 2008, Vol 57, Issue 11, p3090
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-0564