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- Title
A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.
- Authors
Wenzlau, Janet M; Liu, Yu; Yu, Liping; Moua, Ong; Fowler, Kimberly T; Rangasamy, Sampathkumar; Walters, Jay; Eisenbarth, George S; Davidson, Howard W; Hutton, John C
- Abstract
Zinc transporter eight (SLC30A8) is a major target of autoimmunity in human type 1A diabetes and is implicated in type 2 diabetes in genome-wide association studies. The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes.
- Publication
Diabetes, 2008, Vol 57, Issue 10, p2693
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-0522