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- Title
Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
- Authors
Tomlinson, Jeremy W; Finney, Joanne; Gay, Christopher; Hughes, Beverly A; Hughes, Susan V; Stewart, Paul M
- Abstract
The precise molecular mechanisms contributing to the development of insulin resistance, impaired glucose tolerance (IGT), and type 2 diabetes are largely unknown. Altered endogenous glucocorticoid metabolism, including 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which generates active cortisol from cortisone, and 5alpha-reductase (5alphaR), which inactivates cortisol, has been implicated.
- Publication
Diabetes, 2008, Vol 57, Issue 10, p2652
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-0495