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- Title
Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice.
- Authors
Jimenez-Chillaron, Josep C; Isganaitis, Elvira; Charalambous, Marika; Gesta, Stephane; Pentinat-Pelegrin, Thais; Faucette, Ryan R; Otis, Jessica P; Chow, Alice; Diaz, Ruben; Ferguson-Smith, Anne; Patti, Mary-Elizabeth
- Abstract
Low birth weight (LBW) is associated with increased risk of obesity, diabetes, and cardiovascular disease during adult life. Moreover, this programmed disease risk can progress to subsequent generations. We previously described a mouse model of LBW, produced by maternal caloric undernutrition (UN) during late gestation. LBW offspring (F(1)-UN generation) develop progressive obesity and impaired glucose tolerance (IGT) with aging. We aimed to determine whether such metabolic phenotypes can be transmitted to subsequent generations in an experimental model, even in the absence of altered nutrition during the second pregnancy.
- Publication
Diabetes, 2009, Vol 58, Issue 2, p460
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db08-0490