We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.
- Authors
Cani, Patrice D; Bibiloni, Rodrigo; Knauf, Claude; Waget, Aurélie; Neyrinck, Audrey M; Delzenne, Nathalie M; Burcelin, Rémy
- Abstract
Diabetes and obesity are characterized by a low-grade inflammation whose molecular origin is unknown. We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain, and diabetes, and second, that high-fat feeding modulates gut microbiota and the plasma concentration of lipopolysaccharide (LPS), i.e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases.
- Publication
Diabetes, 2008, Vol 57, Issue 6, p1470
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-1403