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- Title
Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.
- Authors
Le Stunff, Catherine; Dechartres, Agnès; Mariot, Virginie; Lotton, Chantal; Trainor, Cecelia; Miraglia Del Giudice, Emanuele; Meyre, David; Bieche, Ivan; Laurendeau, Ingrid; Froguel, Philippe; Zelenika, Diana; Fallin, Dani; Lathrop, Mark; Roméo, Paul-Henri; Bougnères, Pierre
- Abstract
In search of functional polymorphisms associated with the genetics of insulin resistance, we studied a variant in the promoter of PIK3CB, the gene coding for the catalytic p110beta subunit of phosphatidylinositol (PI) 3-kinase, a major effector of insulin action.
- Publication
Diabetes, 2008, Vol 57, Issue 2, p494
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-1273