We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex.
- Authors
Aly, Theresa A; Baschal, Erin E; Jahromi, Mohamed M; Fernando, Maria S; Babu, Sunanda R; Fingerlin, Tasha E; Kretowski, Adam; Erlich, Henry A; Fain, Pamela R; Rewers, Marian J; Eisenbarth, George S
- Abstract
HLA-DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 (DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. Our goal was to search for non-DR/DQ MHC genetic determinants that cause the additional risk in the DR3/4-DQ8 siblings who share both MHC haplotypes.
- Publication
Diabetes, 2008, Vol 57, Issue 3, p770
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-0900