We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.
- Authors
Dogusan, Zeynep; García, Mónica; Flamez, Daisy; Alexopoulou, Lena; Goldman, Michel; Gysemans, Conny; Mathieu, Chantal; Libert, Claude; Eizirik, Decio L; Rasschaert, Joanne
- Abstract
Viral infections contribute to the pathogenesis of type 1 diabetes. Viruses, or viral products such as double-stranded RNA (dsRNA), affect pancreatic beta-cell survival and trigger autoimmunity by unknown mechanisms. We presently investigated the mediators and downstream effectors of dsRNA-induced beta-cell death.
- Publication
Diabetes, 2008, Vol 57, Issue 5, p1236
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-0844