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- Title
Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study.
- Authors
Cordovado, Suzanne K; Zhao, Yuan; Warram, James H; Gong, Hongguang; Anderson, Karen L; Hendrix, Miyono M; Hancock, Laura N; Cleary, Patricia A; Mueller, Patricia W
- Abstract
The purpose of this study was to examine whether known genetic risk factors for type 1 diabetes (HLA-DRB1, -DQA1, and -DQB1 and insulin locus) play a role in the etiology of diabetic nephropathy. RESEARCH DESIGN AND METHODS; Genetic analysis of HLA-DRB1, -DQA1, -DQB1 and the insulin gene (INS) was performed in the Genetics of Kidneys in Diabetes (GoKinD) collection of DNA (European ancestry subset), which includes case patients with type 1 diabetes and nephropathy (n = 829) and control patients with type 1 diabetes but not nephropathy (n = 904). The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy.
- Publication
Diabetes, 2008, Vol 57, Issue 2, p518
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-0826