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- Title
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.
- Authors
Chen, Junqin; Saxena, Geetu; Mungrue, Imran N; Lusis, Aldons J; Shalev, Anath
- Abstract
In diabetes, glucose toxicity affects different organ systems, including pancreatic islets where it leads to beta-cell apoptosis, but the mechanisms are not fully understood. Recently, we identified thioredoxin-interacting protein (TXNIP) as a proapoptotic beta-cell factor that is induced by glucose, raising the possibility that TXNIP may play a role in beta-cell glucose toxicity.
- Publication
Diabetes, 2008, Vol 57, Issue 4, p938
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-0715