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- Title
Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation.
- Authors
Cabric, Sanja; Sanchez, Javier; Lundgren, Torbjörn; Foss, Aksel; Felldin, Marie; Källen, Ragnar; Salmela, Kaija; Tibell, Annika; Tufveson, Gunnar; Larsson, Rolf; Korsgren, Olle; Nilsson, Bo
- Abstract
In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to the poor initial engraftment of the islets. This reaction is triggered by tissue factor and monocyte chemoattractant protein (MCP)-1, expressed by the transplanted pancreatic islets when the islets come in contact with blood in the portal vein. All currently identified systemic inhibitors of the IBMIR are associated with a significantly increased risk of bleeding or other side effects. To avoid systemic treatment, the aim of the present study was to render the islet graft blood biocompatible by applying a continuous heparin coating to the islet surface.
- Publication
Diabetes, 2007, Vol 56, Issue 8, p2008
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-0358