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- Title
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.
- Authors
Huang, Chang-jiang; Lin, Chia-yu; Haataja, Leena; Gurlo, Tatyana; Butler, Alexandra E; Rizza, Robert A; Butler, Peter C
- Abstract
Endoplasmic reticulum (ER) stress-induced apoptosis may be a common cause of cell attrition in diseases characterized by misfolding and oligomerisation of amyloidogenic proteins. The islet in type 2 diabetes is characterized by islet amyloid derived from islet amyloid polypeptide (IAPP) and increased beta-cell apoptosis. We questioned the following: 1) whether IAPP-induced beta-cell apoptosis is mediated by ER stress and 2) whether beta-cells in type 2 diabetes are characterized by ER stress.
- Publication
Diabetes, 2007, Vol 56, Issue 8, p2016
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-0197