We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population.
- Authors
Baschal, Erin E; Aly, Theresa A; Babu, Sunanda R; Fernando, Maria S; Yu, Liping; Miao, Dongmei; Barriga, Katherine J; Norris, Jill M; Noble, Janelle A; Erlich, Henry A; Rewers, Marian J; Eisenbarth, George S
- Abstract
A major goal in genetic studies of type 1A diabetes is prediction of anti-islet autoimmunity and subsequent diabetes in the general population, as >85% of patients do not have a first-degree relative with type 1A diabetes. Given prior association studies, we hypothesized that the strongest candidates for enhancing diabetes risk among DR3-DQB1*0201/DR4-DQB1*0302 individuals would be alleles of DP and DRB1*04 subtypes and, in particular, the absence of reportedly protective alleles DPB1*0402 and/or DRB1*0403.
- Publication
Diabetes, 2007, Vol 56, Issue 9, p2405
- ISSN
1939-327X
- Publication type
Journal Article
- DOI
10.2337/db07-0029