Title

Molecular Switches Regulating Assembly Transitions of Biological Molecules: Tubulin, Amylin and Lipids.

Authors

DAE-WOONG JEONG; SUHO LEE; JUNCHEOL LEE; HYUNWOO JANG; SUNGMUN LEE; MYUNG CHUL CHOI

Abstract

This article presents recent works developing a fundamental understanding of structures and interactions of supramolecular assemblies of biological molecules, in particular, tubulin, amylin and lipids, of which the assembly transition is regulated by molecular switches - tau, taxol, cholesterol, SPAN 80 and lipoic/ascorbic acids. Nanometer to many micrometer scaled structures are solved by combining reciprocal space and real space data resulting from X-ray scattering/reflectivity, fluorescence and electron microscopy.

Subjects

BIOMOLECULES; TUBULINS; MOLECULAR switches; AMYLIN; LIPIDS; X-ray scattering

Publication

AAPPS Bulletin, 2019, Vol 29, Issue 5, p52

ISSN

0218-2203

Publication type

Academic Journal

DOI

10.22661/AAPPSbl.2019.29.5.52