Title

Synthesis, Characterization, and Anti-inflammatory activity of Some Novel Oxazole Derivatives.

Authors

Garg, Ajay Kumar; Singh, Ranjan Kumar; Saxena, Vaibhav; Kr. Sinha, Saurabh; Rao, Sanjay

Abstract

A series of novel oxazole derivatives (A, A1, A2) were synthesized starting from acetone and urea. The compound (A) was obtained by heating it with acetophenone and urea in iodine. Compound (A) on treatment with 4-amino benzaldehyde (Z)-N-(4-amino benzylidine)-4-((E)-Penta-2, 4-diene-2) oxazole-2-amine afforded (A1). Acylation of compound (A) with 4-amino benzoyl chloride to obtain the corresponding N-(4 phenyl oxazole-2- yl)- benzamide (A2). The structures of compounds have been established employing FTIR and ¹H-NMR spectral analysis. All oxazole derivatives were evaluated for anti-inflammatory activity by the carrageenan-induced Rat hind paw method. Derivative A1 shows maximum anti-inflammatory activity.

Subjects

ANTI-inflammatory agents; BENZOYL chloride; ACETOPHENONE; BENZAMIDE; BENZALDEHYDE

Publication

Journal of Drug Delivery & Therapeutics, 2023, Vol 13, Issue 1, p26

ISSN

2250-1177

Publication type

Academic Journal

DOI

10.22270/jddt.v13i1.5719