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Title: Development of An Artificial Male Germ Cell Niche Using Electrospun Poly Vinyl Alcohol/Human Serum Albumin/Gelatin Fibers.
Authors: Borzouie, Zahra; Naghibzadeh, Majid; Talebi, Ali Reza; Pourrajab, Fatemeh; Jebali, Ali; Nikukar, Habib; Molla Hoseini, Hosein; Khoradmehr, Arezoo; Khoradmehr, Arezoo; Sadeghian-Nodoushan, Fatemeh; Aflatoonian, Behrouz; Hekmatimoghaddam, Seyedhossein
Abstract: Recent achievements in stem cell biotechnology, nanotechnology and tissue engineering have led to development of novel approaches in regenerative medicine. Azoospermia is one of the challenging disorders of the reproductive system. Several efforts were made for isolation and culture of testis-derived stem cells to treat male infertility. However, tissue engineering is the best approach to mimic the three dimensional microenvironment of the testis in vitro. We investigated whether human testis-derived cells (hTCs) obtained by testicular sperm extraction (TESE) can be cultured on a homemade scaffold composed of electrospun nanofibers of homogeneous poly (vinyl alcohol)/human serum albumin/gelatin (PVA/HSA/gelatin).
Publication: Cell journal, 2019, Vol 21, Issue 3, p300
ISSN: 2228-5806
Publication type: Journal Article
DOI: 10.22074/cellj.2019.6120

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Development of An Artificial Male Germ Cell Niche Using Electrospun Poly Vinyl Alcohol/Human Serum Albumin/Gelatin Fibers.