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- Title
Identification of two neutralizing human single-chain variable fragment antibodies targeting <i>Staphylococcus aureus</i> alpha-hemolysin.
- Authors
Piri-Gavgani, Somayeh; Ghanei, Mostafa; Fateh, Abolfazl; Siadat, Seyed Davar; Nematollahi, Leila; Rahimi-Jamnani, Fatemeh
- Abstract
The inability of the host immune system to defeat Staphylococcus aureus is due to various secreted virulent factors such as leukocidins, superantigens, and hemolysins, which interrupt the function of immune components. Alpha-hemolysin is one of the most studied cytolysins due to its pronounced effect on developing staphylococcal infections. Alpha-hemolysin-neutralizing antibodies are among the best candidates for blocking the toxin activity and preventing S. aureus pathogenesis.
- Publication
Iranian journal of basic medical sciences, 2022, Vol 25, Issue 10, p1207
- ISSN
2008-3866
- Publication type
Journal Article
- DOI
10.22038/IJBMS.2022.64103.14253