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Title: Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome.
Authors: Shaaban, Zahra; Khoradmehr, Arezoo; Amiri-Yekta, Amir; Jafarzadeh Shirazi, Mohammad Reza; Tamadon, Amin
Abstract: One of the common heterogeneous reproductive disorders in women of childbearing age is polycystic ovary syndrome (PCOS). It is characterized by lack of fertility due to anovulatory cycles, hyperandrogenemia, polycystic ovaries, hyperinsulinemia, and obesity. Both reproductive anomalies and metabolic disorders are involved in PCOS pathology. Although the role of increased levels of androgens in initiation of PCOS is almost proven, mechanisms of PCOS pathophysiology are not clear. Here we discuss roles of altered metabolic conditions, obesity, and chronic inflammation in PCOS pathophysiology.
Publication: Iranian journal of basic medical sciences, 2019, Vol 22, Issue 12, p1378
ISSN: 2008-3866
Publication type: Journal Article
DOI: 10.22038/IJBMS.2019.14029

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Pathophysiologic mechanisms of obesity- and chronic inflammation-related genes in etiology of polycystic ovary syndrome.