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- Title
Reducing spatial flaws in oligonucleotide arrays by using neighborhood information.
- Authors
Arteaga-Salas, Jose Manuel; Harrison, Andrew P; Upton, Graham J G
- Abstract
We address the problem of detection and correction of spatial flaws in oligonucleotide microarrays. We present two similar procedures, of which one is intended solely for use with replicates and the other has wider applicability. By constructing a set of replicates, with one realistically flawed, we are able to examine the extent to which our procedures are capable of repairing the flaw. We find that, for this purpose, our procedures are superior to the existing 'Harshlight' procedure.
- Publication
Statistical applications in genetics and molecular biology, 2008, Vol 7, Issue 1, pArticle29
- ISSN
1544-6115
- Publication type
Journal Article
- DOI
10.2202/1544-6115.1383