Title

State-of-the-art of the Bone Morphogenetic Protein research field: 13th International BMP Conference, Dubrovnik 2022.

Authors

Štoković, Nikola; Ivanjko, Natalia; Jelić, Ivona Matić; Milešević, Marina; Rumenović, Viktorija; Blažević, Valentina; Rogina, Lucija; Bastalić, Ivančica; Erjavec, Igor; Nikšić, Tatjana Bordukalo; Kufner, Vera; Adanić, Dora; Perić, Mihaela; Pećina, Marko; Sampath, T. Kuber; Vukičević, Slobodan

Abstract

The 13th International BMP Conference was held in October 2022 in Dubrovnik. The conference was attended by more than 240 participants from North America, Europe, Asia, and Australia who got an insight into the latest achievements in basic, translational, and clinical research of BMP molecules through 75 lectures categorized into several scientific sections. This review paper provides the most important novel findings on the structure, function, and signaling of BMPs, the role of BMPs in patterning and organoids as well as the role of BMP in metabolism. Moreover, we discussed the role of BMPs in various diseases including cancer pathogenesis, pulmonary arterial hypertension, and fibrodysplasia ossificans progressiva (FOP). Finally, we provided an overview of the new BMP-based therapies in regenerative medicine that are currently in different stages of preclinical and clinical trials.

Subjects

DUBROVNIK (Croatia); BONE morphogenetic proteins; FIBRODYSPLASIA ossificans progressiva; PULMONARY arterial hypertension; CONFERENCES & conventions; REGENERATIVE medicine

Publication

Rad Hrvatske Akademije Znanosti i Umjetnosti. Medicinske Znanosti, 2022, Vol 553, Issue 60/61, p84

ISSN

1330-5301

Publication type

Academic Journal

DOI

10.21857/ypn4ocd309