We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Seattle Structural Genomics Center for Infectious Disease (SSGCID).
- Authors
Myler, P J; Stacy, R; Stewart, L; Staker, B L; Van Voorhis, W C; Varani, G; Buchko, G W
- Abstract
The NIAID-funded Seattle Structural Genomics Center for Infectious Disease (SSGCID) is a consortium established to apply structural genomics approaches to potential drug targets from NIAID priority organisms for biodefense and emerging and re-emerging diseases. The mission of the SSGCID is to determine approximately 400 protein structures over the next five years. In order to maximize biomedical impact, ligand-based drug-lead discovery campaigns will be pursued for a small number of high-impact targets. Here we review the center's target selection processes, which include pro-active engagement of the infectious disease research and drug therapy communities to identify drug targets, essential enzymes, virulence factors and vaccine candidates of biomedical relevance to combat infectious diseases. This is followed by a brief overview of the SSGCID structure determination pipeline and ligand screening methodology. Finally, specifics of our resources available to the scientific community are presented. Physical materials and data produced by SSGCID will be made available to the scientific community, with the aim that they will provide essential groundwork benefiting future research and drug discovery.
- Publication
Infectious disorders drug targets, 2009, Vol 9, Issue 5, p493
- ISSN
2212-3989
- Publication type
Journal Article
- DOI
10.2174/187152609789105687