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- Title
A RhoA-derived peptide inhibits human immunodeficiency virus-1 entry in vitro.
- Authors
Maselko, Maciej; Ward, Casey; Pastey, Manoj
- Abstract
RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA 77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.
- Publication
Current HIV research, 2011, Vol 9, Issue 1, p1
- ISSN
1873-4251
- Publication type
Journal Article
- DOI
10.2174/157016211794582605