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- Title
The antimicrobial peptide LL-37 inhibits HIV-1 replication.
- Authors
Bergman, Peter; Walter-Jallow, Lilian; Broliden, Kristina; Agerberth, Birgitta; Söderlund, Johan
- Abstract
The antimicrobial peptide LL-37 is the only cathelicidin that has been described in humans. LL-37 exerts chemotactic, immunomodulatory and angiogenic effects; activities that are mediated through binding to the formyl peptide receptor like (FPRL)-1 receptor. Agonistic ligation of FPRL-1 can also induce down-regulation of HIV-1 chemokine receptors and reduce susceptibility to HIV-1 infection in vitro. Therefore, we have evaluated the capacity of LL-37 to inhibit HIV-1 infection in vitro. Here we demonstrate that LL-37 inhibits HIV-1 replication in PBMC, including primary CD4(+) T cells. This inhibition was readily reproduced using various HIV-1 isolates without detectable changes in the target cell expression of HIV-1 chemokine receptors. Accordingly, the HIV-1 inhibitory effect was shown to be independent of FPRL-1 signalling. Given the epithelial expression of LL-37, it may contribute to the local protection against HIV-1 infection.
- Publication
Current HIV research, 2007, Vol 5, Issue 4, p410
- ISSN
1873-4251
- Publication type
Journal Article
- DOI
10.2174/157016207781023947