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- Title
Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease.
- Authors
Ghosh, Aurn K; Kumaragurubaran, Nagaswamy; Tang, Jordan
- Abstract
The amyloid-beta (Abeta) peptide is the principal components of the senile plaques found in the brains of patients with Alzheimer's disease (AD). The poorly soluble 40-42 amino acid peptide, formed from the cleavage of the Abeta precursor protein (APP) by two proteases, is believed to play a central role in the pathogenesis of AD. Beta-secretase (memapsin 2, BACE1), a membrane-anchored aspartic protease, is responsible for the initial step of APP cleavage leading to the generation of Abeta. Identification and structural determination of beta-secretase have established it to be a primary drug target for AD therapy and stimulated active studies on the inhibitors of this protease. Here we review more recent developments in the design and testing of structure-based beta-secretase inhibitors.
- Publication
Current topics in medicinal chemistry, 2005, Vol 5, Issue 16, p1609
- ISSN
1568-0266
- Publication type
Journal Article
- DOI
10.2174/156802605775009711