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- Title
HSP27: mechanisms of cellular protection against neuronal injury.
- Authors
Stetler, R A; Gao, Y; Signore, A P; Cao, G; Chen, J
- Abstract
The heat shock protein (HSP) family has long been associated with a generalized cellular stress response, particularly in terms of recognizing and chaperoning misfolded proteins. While HSPs in general appear to be protective, HSP27 has recently emerged as a particularly potent neuroprotectant in a number of diverse neurological disorders, ranging from ALS to stroke. Although its robust protective effect on a number of insults has been recognized, the mechanisms and regulation of HSP27's protective actions are still undergoing intense investigation. On the basis of recent studies, HSP27 appears to have a dynamic and diverse range of function in cellular survival. This review provides a forum to compare and contrast recent literature exploring the protective mechanism and regulation of HSP27, focusing on neurological disorders in particular, as they represent a range from protein aggregate-associated diseases to acute stress.
- Publication
Current molecular medicine, 2009, Vol 9, Issue 7, p863
- ISSN
1875-5666
- Publication type
Journal Article
- DOI
10.2174/156652409789105561