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- Title
The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins.
- Authors
Oakes, Scott A; Lin, Stephen S; Bassik, Michael C
- Abstract
Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.
- Publication
Current molecular medicine, 2006, Vol 6, Issue 1, p99
- ISSN
1566-5240
- Publication type
Journal Article
- DOI
10.2174/156652406775574587