We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Antidepressants and neuroinflammation: Can antidepressants calm glial rage down?
- Authors
Hashioka, S
- Abstract
Neuroinflammation is traditionally defined as the brain's innate immune response and is also considered to be a glial-cell propagated inflammation. Increasing evidence indicates that neuroinflammation plays an important role in some cases of major depression and also that antidepressants possess anti-neuroinflammatory properties. Inhibition of neuroinflammation may represent a novel mechanism of action of antidepressant treatment. In vivo studies with animal models of neurological conditions have shown that various types of antidepressants exert inhibitory effects on the expression of inflammatory mediators, including cytokines, as well as on both microgliosis and astrogliosis in the inflamed CNS. In vitro studies using pathologically activated rodent microglia or mixed glial cells have demonstrated that various types of antidepressants diminish glial generation of inflammatory molecules. One of the most plausible mechanisms of such anti-neuroinflammatory efficacy of the drugs, as well as their antidepressant actions, seems to involve elevated intracellular cAMP levels. But the exact mechanism has still to be elucidated.
- Publication
Mini reviews in medicinal chemistry, 2011, Vol 11, Issue 7, p555
- ISSN
1875-5607
- Publication type
Journal Article
- DOI
10.2174/138955711795906888