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Title
Inhibitors of c-jun-N-terminal kinase (JNK).
Authors
LoGrasso, Philip; Kamenecka, Theodore
Abstract
Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.
Publication
Mini reviews in medicinal chemistry, 2008, Vol 8, Issue 8, p755