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- Title
New lead generation strategies for protein kinase inhibitors - fragment based screening approaches.
- Authors
Gill, Adrian
- Abstract
The protein kinase superfamily represents both an enormous opportunity and a unique challenge for drug discovery. Protein kinases play central roles in the cellular economy and it is well known that a large number of diseases involve aberrant protein kinase activity. This review discusses how fragment based screening strategies, such as virtual screening, NMR and high-throughput X-ray crystallography are being employed to identify new chemo-types to produce the next generation of protein kinase inhibitors.
- Publication
Mini reviews in medicinal chemistry, 2004, Vol 4, Issue 3, p301
- ISSN
1389-5575
- Publication type
Journal Article
- DOI
10.2174/1389557043487385